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Test ID: ADULT Adulterants Survey, Random, Urine

Useful For

Assessment of possible adulteration of a urine specimen submitted for drug of abuse testing


Providing the creatinine concentration for normalization purposes

Testing Algorithm

See Adulterant Survey Algorithm in Special Instructions.

Special Instructions

Reporting Name

Adulterants Survey, U

Specimen Type


Specimen Required

Container/Tube: Plastic, 60-mL urine bottle

Specimen Volume: 1.5 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.

Additional Information:

1. For situations where chain of custody is required, a Chain-of-Custody Kit (T282) is available. For chain-of-custody information, see ADLTX / Adulterants Survey, Chain of Custody, Random, Urine.

2. Submitting less than 1.5 mL may compromise the ability to perform all necessary testing.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  72 hours

Clinical Information

Specimen adulteration is the manipulation of a sample that may cause falsely negative test results for the presence of drugs of abuse. Common adulterants that may affect testing are water, soap, bleach, vinegar, oxidants, and salt. The adulteration testing includes assessment of creatinine concentration, pH, urine specific gravity, presence or absence of an oxidant, and presence or absence of nitrite.


See Adulterant Survey Algorithm in Special Instructions.

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 2 days

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
ADULT Adulterants Survey, U 58714-7


Result ID Test Result Name Result LOINC Value
20606 Creatinine, U 2161-8
22312 Specific Gravity 5810-7
23509 pH 2756-5
23511 Oxidants 58714-7
23510 Nitrites 32710-6
30914 Comment 48767-8

Method Name

Spectrophotometry (SP)

Reference Values

Cutoff concentrations

Oxidants: 200 mg/L

Nitrites: 500 mg/L

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.


If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen. 

Clinical Reference

1. US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration (SAMHSA): Mandatory Guidelines for Federal Workplace Drug Testing Programs. Federal Register. 2017 January 23;82(13):FR 7920. Available at:

2. US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration (SAMHSA): Drug-Free Workplace Guidelines and Resources Updated June 7, 2021. Accessed September 27, 2021. Available at:

Mayo Clinic Laboratories | Therapeutics Catalog Additional Information:

mml-adulterants, mml-substancemonitoring